EZH2 inhibition blocks multiple myeloma cell growth through upregulation of epithelial tumor suppressor genes
H Hernando, KA Gelato, R Lesche, G Beckmann… – Molecular cancer …, 2015
Abstract Multiple myeloma is a plasma cell malignancy characterized by marked
heterogeneous genomic instability including frequent genetic alterations in epigenetic
enzymes. In particular, the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2 …
heterogeneous genomic instability including frequent genetic alterations in epigenetic
enzymes. In particular, the histone methyltransferase Enhancer of Zeste Homolog 2 (EZH2 …
HSP20 Peptide Decreases Human Airway Constriction Downstream of β2 Adrenergic Receptor
A Banathy, J Cheung-Flynn, K Goleniewska, KL Boyd… – American journal of …, 2016
Severe bronchospasm refractory to β-agonists is a challenging aspect of asthma therapy
and novel therapeutics are needed. β-agonist-induced airway smooth muscle (ASM)
relaxation is associated with increases in the phosphorylation of the small heat-shock …
and novel therapeutics are needed. β-agonist-induced airway smooth muscle (ASM)
relaxation is associated with increases in the phosphorylation of the small heat-shock …
Epidermal Growth Factor Receptor Signaling to the Mitogen Activated Protein Kinase Pathway Bypasses Ras in Pancreatic Cancer Cells
S Lee, EL Heinrich, J Lu, W Lee, AH Choi, C Luu… – Pancreas, 2016
Objective: Epidermal growth factor (EGF) receptor (EGFR/HER1) is overexpressed in human
pancreatic cancers. However, anti-EGFR therapy does not exhibit significant therapeutic
activity with oncogenic K-ras mutation. We sought to assess the signaling relationship …
pancreatic cancers. However, anti-EGFR therapy does not exhibit significant therapeutic
activity with oncogenic K-ras mutation. We sought to assess the signaling relationship …
Compensating for atrioventricular block using a nucleic acid encoding a sodium channel or gap junction protein
IS Cohen, PR Brink, MR Rosen, RB Robinson – US Patent App. 12/921,395, 2009
A method of increasing the velocity of AV conduction in a mammal that may be in heart block
or at risk of heart block by causing, in an AV node and/or His bundle having less than normal
conduction speed, the expression of a sodium channel or gap junction protein, such as …
or at risk of heart block by causing, in an AV node and/or His bundle having less than normal
conduction speed, the expression of a sodium channel or gap junction protein, such as …
Role of mTOR Downstream Effector Signaling Molecules in Francisella Tularensis Internalization by Murine Macrophages
MW Edwards, JA Aultman, G Harber, JM Bhatt, E Sztul… – PloS one, 2013
Abstract Francisella tularensis is an infectious, gram-negative, intracellular microorganism,
and the cause of tularemia. Invasion of host cells by intracellular pathogens like Francisella
is initiated by their interaction with different host cell membrane receptors and the rapid …
and the cause of tularemia. Invasion of host cells by intracellular pathogens like Francisella
is initiated by their interaction with different host cell membrane receptors and the rapid …
Green Tea Epigallocatechin-3-Gallate Suppresses Autoimmune Arthritis Through Indoleamine-2, 3-Dioxygenase Expressing Dendritic Cells and the Nuclear Factor, …
SY Min, M Yan, SB Kim, S Ravikumar, SR Kwon… – Journal of Inflammation, 2015
Background The activity of one of the major catechins in Green Tea, the polyphenol (−)-
epigallocatechin-3-gallate (EGCG), has been shown to have a variety of health benefits.
Recent studies suggest that EGCG can modulate both the innate and adaptive arms of the …
epigallocatechin-3-gallate (EGCG), has been shown to have a variety of health benefits.
Recent studies suggest that EGCG can modulate both the innate and adaptive arms of the …
Retinal ganglion cells downregulate gene expression and lose their axons within the optic nerve head in a mouse glaucoma model
I Soto, E Oglesby, BP Buckingham, JL Son… – The Journal of …, 2008
Abstract Little is known about molecular changes occurring within retinal ganglion cells
(RGCs) before their death in glaucoma. Taking advantage of the fact that γ-synuclein (Sncg)
mRNA is expressed specifically and highly in adult mouse RGCs, we show in the DBA/2J …
(RGCs) before their death in glaucoma. Taking advantage of the fact that γ-synuclein (Sncg)
mRNA is expressed specifically and highly in adult mouse RGCs, we show in the DBA/2J …
Seroprevalences of Toxoplasma gondii and Neospora caninum in Pet Rabbits in Japan
D Salman, E Oohashi, AEA Mohamed… – Journal of Veterinary …, 2014
The potential contamination of Toxoplasma gondii and Neospora caninum oocysts in the
human environment is a concern from the public health viewpoint. However, estimation of
their seroprevalences in humans cannot be performed in a manner that distinguishes …
human environment is a concern from the public health viewpoint. However, estimation of
their seroprevalences in humans cannot be performed in a manner that distinguishes …
Overproduction of Toxoplasma gondii cyclophilin-18 regulates host cell migration and enhances parasite dissemination in a CCR5-independent manner
HM Ibrahim, M Nishimura, S Tanaka, W Awadin… – BMC microbiology, 2014
Background Toxoplasma gondii hijacks host cells to allow it to disseminate throughout a
host animal; however, the migratory machinery involved in this process has not been well
characterized. We examined the functional role of T. gondii cyclophilin 18 (TgCyp18) in …
host animal; however, the migratory machinery involved in this process has not been well
characterized. We examined the functional role of T. gondii cyclophilin 18 (TgCyp18) in …
Role of Cyclic Nucleotide-Dependent Actin Cytoskeletal Dynamics:[Ca 2+] i and Force Suppression in Forskolin-Pretreated Porcine Coronary Arteries
KM Hocking, FJ Baudenbacher, G Putumbaka… – PloS one, 2013
Abstract Initiation of force generation during vascular smooth muscle contraction involves a
rise in intracellular calcium ([Ca 2+] i) and phosphorylation of myosin light chains (MLC).
However, reversal of these two processes alone does not account for the force inhibition …
rise in intracellular calcium ([Ca 2+] i) and phosphorylation of myosin light chains (MLC).
However, reversal of these two processes alone does not account for the force inhibition …
5-alpha-reductase type I (SRD5A1) is up-regulated in non-small cell lung cancer but does not impact proliferation, cell cycle distribution or apoptosis
FG Kapp, A Sommer, T Kiefer, G Dölken, B Haendler – Cancer cell international, 2012
Background Non-small cell lung cancer (NSCLC) is one of the most frequent malignancies
and has a high mortality rate due to late detection and lack of efficient treatments. Identifying
novel drug targets for this indication may open the way for new treatment strategies. …
and has a high mortality rate due to late detection and lack of efficient treatments. Identifying
novel drug targets for this indication may open the way for new treatment strategies. …
Human and pneumococcal cell surface glyceraldehyde-3-phosphate dehydrogenase (GAPDH) proteins are both ligands of human C1q protein
R Terrasse, P Tacnet-Delorme, C Moriscot, J Pérard… – Journal of Biological …, 2012
↵3 To whom correspondence may be addressed: Pneumococcus Group (PG), Inst. de Biologie
Structurale Jean-Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France. Tel.:
33-4-38-78-56-34; Fax: 33-4-38-78-54-94; E-mail: anne-marie.di-guilmi{at}ibs.fr.
Structurale Jean-Pierre Ebel, 41 rue Jules Horowitz, 38027 Grenoble Cedex 1, France. Tel.:
33-4-38-78-56-34; Fax: 33-4-38-78-54-94; E-mail: anne-marie.di-guilmi{at}ibs.fr.
Acyl-CoA thioesterase-2 facilitates mitochondrial fatty acid oxidation in the liver
C Moffat, L Bhatia, T Nguyen, P Lynch, M Wang… – Journal of lipid research, 2014
Abstract Acyl-CoA thioesterase (Acot) 2 localizes to the mitochondrial matrix and hydrolyses
long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxidative
tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role …
long-chain fatty acyl-CoA into free FA and CoASH. Acot2 is expressed in highly oxidative
tissues and is poised to modulate mitochondrial FA oxidation (FAO), yet its biological role …
Modulation of the Sensitivity of Jurkat T-Cells to Inhibition of Protein Synthesis by Tumor Necrosis Factor α-Related Apoptosis-Inducing Ligand
A Elia, IR Powley, M MacFarlane, MJ Clemens – Journal of Interferon & Cytokine …, 2014
Tumor necrosis factor α-related apoptosis-inducing ligand (TRAIL) is a potent inducer of
apoptosis in Jurkat T lymphoma cells. One of the characteristics of the phase preceding
overt apoptosis is the marked downregulation of protein synthesis. We have investigated …
apoptosis in Jurkat T lymphoma cells. One of the characteristics of the phase preceding
overt apoptosis is the marked downregulation of protein synthesis. We have investigated …
Mechanisms of interferon‐beta‐induced inhibition of Toxoplasma gondii growth in murine macrophages and embryonic fibroblasts: role of immunity‐related GTPase …
ME Mahmoud, F Ui, D Salman, M Nishimura… – Cellular microbiology, 2015
Summary The apical complex of Toxoplasma gondii enables it to invade virtually all
nucleated cells in warm-blooded animals, including humans, making it a parasite of global
importance. Anti-T. gondii cellular defence mechanisms depend largely on interferon (IFN) …
nucleated cells in warm-blooded animals, including humans, making it a parasite of global
importance. Anti-T. gondii cellular defence mechanisms depend largely on interferon (IFN) …
LncRNA uc. 48+ is involved in diabetic neuropathic pain mediated by the P2X3 receptor in the dorsal root ganglia
S Wang, H Xu, L Zou, J Xie, H Wu, B Wu, Z Yi, Q Lv… – Purinergic signalling, 2015
Abstract Some long non-coding RNAs (lncRNAs) participate in physiological processes that
maintain cellular and tissue homeostasis, and thus, the dysregulated expression of lncRNAs
is involved in the onset and progression of many pathological conditions. Research has …
maintain cellular and tissue homeostasis, and thus, the dysregulated expression of lncRNAs
is involved in the onset and progression of many pathological conditions. Research has …
Cyclin-Cyclin-dependent Kinase Regulatory Response Is Linked to Substrate Recognition
ME Cuomo, GM Platt, LH Pearl, S Mittnacht – Journal of Biological Chemistry, 2011
Abstract Cyclin/cyclin-dependent kinase (CDK) complexes are critical regulators of cellular
proliferation. A complex network of regulatory mechanisms has evolved to control their
activity, including activating and inactivating phosphorylation of the catalytic CDK subunit …
proliferation. A complex network of regulatory mechanisms has evolved to control their
activity, including activating and inactivating phosphorylation of the catalytic CDK subunit …
Dendritic arborization and spine dynamics are abnormal in the mouse model of MECP2 duplication syndrome
M Jiang, RT Ash, SA Baker, B Suter, A Ferguson… – The Journal of …, 2013
Abstract MECP2 duplication syndrome is a childhood neurological disorder characterized by
intellectual disability, autism, motor abnormalities, and epilepsy. The disorder is caused by
duplications spanning the gene encoding methyl-CpG-binding protein-2 (MeCP2), a …
intellectual disability, autism, motor abnormalities, and epilepsy. The disorder is caused by
duplications spanning the gene encoding methyl-CpG-binding protein-2 (MeCP2), a …
Endorepellin, perlecan angiostatic module, interacts with both the [alpha] 2 [beta] 1 integrin and VEGFreceptor 2: A dual receptor antagonism
Abstract Endorepellin, the C-terminal module of perlecan, negatively regulates
angiogenesis counter to its proangiogenic parental molecule. Endorepellin binds α2β1i
integrin on endothelial cells and triggers a signaling cascade that leads to disruption of …
angiogenesis counter to its proangiogenic parental molecule. Endorepellin binds α2β1i
integrin on endothelial cells and triggers a signaling cascade that leads to disruption of …
Nucleotide composition of cellular internal ribosome entry sites defines dependence on NF45 and predicts a posttranscriptional mitotic regulon
ABSTRACT The vast majority of cellular mRNAs initiate their translations through a well-
defined mechanism of ribosome recruitment that occurs at the 5′-terminal 7-
methylguanosine cap with the help of several canonical protein factors. A subset of …
defined mechanism of ribosome recruitment that occurs at the 5′-terminal 7-
methylguanosine cap with the help of several canonical protein factors. A subset of …
Adaptations of the Endothelin System After Exercise Training in a Porcine Model of Ischemic Heart Disease
JC Robles, CL Heaps – Microcirculation, 2015
Objective To the test the hypothesis that exercise training would increase endothelin-
mediated vasoconstriction in collateral-dependent arteries via enhanced contribution of ET
A. Methods An ameroid constrictor was surgically placed around the proximal LCX artery …
mediated vasoconstriction in collateral-dependent arteries via enhanced contribution of ET
A. Methods An ameroid constrictor was surgically placed around the proximal LCX artery …
Converging pathways involving microRNA-206 and the RNA-binding protein KSRP control post-transcriptionally utrophin A expression in skeletal muscle
A Amirouche, H Tadesse, P Miura, G Bélanger… – Nucleic acids research, 2014
Abstract Several reports have previously highlighted the potential role of miR-206 in the post-
transcriptional downregulation of utrophin A in cultured cells. Along those lines, we recently
identified K-homology splicing regulator protein (KSRP) as an important negative …
transcriptional downregulation of utrophin A in cultured cells. Along those lines, we recently
identified K-homology splicing regulator protein (KSRP) as an important negative …
Method of determining a concentration of analytes of interest in a sample
F Mallwitz, U Dahmen-Levison, D Levison, S Levison – US Patent 8,173,379, 2012
A method of determining a concentration of analytes of interest in a sample reaction mixture
is disclosed. The method can include measuring intensities of the polarized fluorescence of
at least one comparative reaction mixture containing different, known amounts of the …
is disclosed. The method can include measuring intensities of the polarized fluorescence of
at least one comparative reaction mixture containing different, known amounts of the …
RING1A and BMI1 bookmark active genes via ubiquitination of chromatin-associated proteins
Abstract During mitosis the chromatin undergoes dramatic architectural changes with the
halting of the transcriptional processes and evacuation of nearly all transcription associated
machinery from genes and promoters. Molecular bookmarking of genes during mitosis is a …
halting of the transcriptional processes and evacuation of nearly all transcription associated
machinery from genes and promoters. Molecular bookmarking of genes during mitosis is a …
Preclinical evaluation of multistep targeting of diasialoganglioside GD2 using an IgG-scFv bispecific antibody with high affinity for GD2 and DOTA metal complex
SM Cheal, H Xu, H Guo, PB Zanzonico, SM Larson… – Molecular cancer …, 2014
Abstract Bispecific antibodies (BsAb) have proven to be useful targeting vectors for
pretargeted radioimmunotherapy (PRIT). We sought to overcome key PRIT limitations such
as high renal radiation exposure and immunogenicity (eg, of streptavidin–antibody fusions …
pretargeted radioimmunotherapy (PRIT). We sought to overcome key PRIT limitations such
as high renal radiation exposure and immunogenicity (eg, of streptavidin–antibody fusions …
Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel …
SA Cross, DR Cook, AWS Chi, PJ Vance, LL Kolson… – The Journal of Immunology, 2011
Abstract Despite antiretroviral therapy (ART), HIV infection promotes cognitive dysfunction
and neurodegeneration through persistent inflammation and neurotoxin release from
infected and/or activated macrophages/microglia. Furthermore, inflammation and immune …
and neurodegeneration through persistent inflammation and neurotoxin release from
infected and/or activated macrophages/microglia. Furthermore, inflammation and immune …
Olive oil compounds inhibit the paracrine regulation of TNF-α-induced endothelial cell migration through reduced glioblastoma cell cyclooxygenase-2 expression
S Lamy, AB Saad, A Zgheib, B Annabi – The Journal of nutritional biochemistry, 2016
Abstract The established causal relationship between the chronic inflammatory
microenvironment, tumor development and cancer recurrence has provided leads for
developing novel preventive strategies. Accumulating experimental, clinical and …
microenvironment, tumor development and cancer recurrence has provided leads for
developing novel preventive strategies. Accumulating experimental, clinical and …
Pre-clinical evaluation of a replication-competent recombinant adenovirus serotype 4 vaccine expressing influenza H5 hemagglutinin
J Alexander, S Ward, J Mendy, DJ Manayani… – PLoS One, 2012
Background Influenza virus remains a significant health and social concern in part because
of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1
vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, …
of newly emerging strains, such as avian H5N1 virus. We have developed a prototype H5N1
vaccine using a recombinant, replication-competent Adenovirus serotype 4 (Ad4) vector, …
Cellular source and amount of VEGF and PDGF in tumors determine response to angiogenesis inhibitors
B Sennino, F Kuhnert, SP Tabruyn, MR Mancuso… – Cancer research, 2009
Abstract Vascular endothelial growth factor (VEGF), platelet-derived growth factor (PDGF),
and their receptors are important targets in cancer therapy based on angiogenesis
inhibition. However, it is unclear whether inhibition of VEGF and PDGF together is more …
and their receptors are important targets in cancer therapy based on angiogenesis
inhibition. However, it is unclear whether inhibition of VEGF and PDGF together is more …
Disruption of the protein interaction between FAK and IGF-1R inhibits melanoma tumor growth
DA Ucar, EV Kurenova, TJ Garrett, WG Cance… – Carcinogenesis, 2011
Abstract Previously, we have shown that focal adhesion kinase (FAK) and insulin-like growth
factor receptor-1 (IGF-1R) directly interact with each other and, thereby, activate crucial
signaling pathways that benefit cancer cells. Inhibition of FAK and IGF-1R function have …
factor receptor-1 (IGF-1R) directly interact with each other and, thereby, activate crucial
signaling pathways that benefit cancer cells. Inhibition of FAK and IGF-1R function have …
High‐yield rapid production of hepatitis B surface antigen in plant leaf by a viral expression system
Z Huang, K LePore, G Elkin, Y Thanavala, HS Mason – Plant biotechnology journal, 2008
Summary Recombinant hepatitis B surface antigen (HBsAg) constitutes currently used
vaccines against hepatitis B virus, and has been successfully employed as a carrier for
foreign epitopes. With the aim of developing an inexpensive, easily administered vaccine …
vaccines against hepatitis B virus, and has been successfully employed as a carrier for
foreign epitopes. With the aim of developing an inexpensive, easily administered vaccine …
Inhibition of protein-tyrosine phosphatase 1B (PTP1B) mediates ubiquitination and degradation of Bcr-Abl protein
D Alvira, R Naughton, L Bhatt, S Tedesco, WD Landry… – Journal of Biological …, 2011
Abstract Chronic myelogenous leukemia (CML) is a myeloproliferative disorder
characterized at the molecular level by the expression of Bcr-Abl, a chimeric protein with
deregulated tyrosine kinase activity. The protein-tyrosine phosphatase 1B (PTP1B) is up- …
characterized at the molecular level by the expression of Bcr-Abl, a chimeric protein with
deregulated tyrosine kinase activity. The protein-tyrosine phosphatase 1B (PTP1B) is up- …
Genome Protection by the 9-1-1 Complex Subunit HUS1 Requires Clamp Formation, DNA Contacts, and ATR Signaling-independent Effector Functions
PX Lim, DR Patel, KE Poisson, M Basuita, C Tsai… – Journal of Biological …, 2015
↵1 To whom correspondence should be addressed: Dept. of Biomedical Sciences, Cornell
University, Tower Rd., Ithaca, NY 14853-6401. Tel.: 607-253-4443; Fax: 607-253-4212;
E-mail: rsw26{at}cornell.edu. … Background: The 9-1-1 complex mediates checkpoint …
University, Tower Rd., Ithaca, NY 14853-6401. Tel.: 607-253-4443; Fax: 607-253-4212;
E-mail: rsw26{at}cornell.edu. … Background: The 9-1-1 complex mediates checkpoint …
Transforming growth factor b1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer- …
X LiuÃ, YS Piao, JT Arnold – Carcinogenesis, 2011
Transforming growth factor b1 (TGF-b1) increases dehydroepiandrosterone (DHEA)
metabolism to androgens and prostatespecific antigen (PSA) in a prostate tissue model
where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) …
metabolism to androgens and prostatespecific antigen (PSA) in a prostate tissue model
where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover (RC) …
Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer’s disease
DE Hurtado, L Molina-Porcel, JC Carroll… – The Journal of …, 2012
Abstract Glycogen synthase kinase-3 (GSK-3) is linked to the pathogenesis of Alzheimer’s
disease (AD), senile plaques (SPs), and neurofibrillary tangles (NFTs), but the specific
contributions of each of the GSK-3 α and β isoforms to mechanisms of AD have not been …
disease (AD), senile plaques (SPs), and neurofibrillary tangles (NFTs), but the specific
contributions of each of the GSK-3 α and β isoforms to mechanisms of AD have not been …
Androgen‐induced PSA expression requires not only activation of AR but also endogenous IGF‐I or IGF‐I/PI3K/Akt signaling in human prostate cancer epithelial cells
X Liu, RY Choi, SM Jawad, JT Arnold – The Prostate, 2011
BACKGROUND Prostate cancer (PrCa) risk is positively associated with levels of insulin-like
growth factor I (IGF-I) and prostate specific antigen (PSA), both androgen receptor (AR)
signaling target genes in PrCa cells. Although activated AR is required for androgen- …
growth factor I (IGF-I) and prostate specific antigen (PSA), both androgen receptor (AR)
signaling target genes in PrCa cells. Although activated AR is required for androgen- …
Post-transcriptional homeostasis and regulation of MCM2–7 in mammalian cells
CH Chuang, D Yang, G Bai, A Freeland, SC Pruitt… – Nucleic acids research, 2012
Abstract The MiniChromosome Maintenance 2-7 (MCM2-7) complex provides essential
replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic
instability (GIN), leading to cancer and developmental defects in mice. Remarkably, …
replicative helicase function. Insufficient MCMs impair the cell cycle and cause genomic
instability (GIN), leading to cancer and developmental defects in mice. Remarkably, …
Expression profile and mitochondrial colocalization of Tdp1 in peripheral human tissues
HK Fam, MK Chowdhury, C Walton, K Choi… – Journal of molecular …, 2013
Abstract Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a DNA repair enzyme that processes
blocked 3′ ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with
axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of …
blocked 3′ ends of DNA breaks. Functional loss of Tdp1 causes spinocerebellar ataxia with
axonal neuropathy type 1 (SCAN1). Based on the prominent cytoplasmic expression of …
Astrocytic TDP-43 pathology in Alexander disease
AK Walker, CMLP Daniels, JE Goldman… – The Journal of …, 2014
Abstract Alexander disease (AxD) is a rare neurodegenerative disorder characterized
pathologically by the presence of eosinophilic inclusions known as Rosenthal fibers (RFs)
within astrocytes, and is caused by dominant mutations in the coding region of the gene …
pathologically by the presence of eosinophilic inclusions known as Rosenthal fibers (RFs)
within astrocytes, and is caused by dominant mutations in the coding region of the gene …
ANG4043, a Novel Brain-Penetrant Peptide–mAb Conjugate, Is Efficacious against HER2-Positive Intracranial Tumors in Mice
A Regina, M Demeule, S Tripathy, S Lord-Dufour… – Molecular cancer …, 2015
Abstract Anti-HER2 monoclonal antibodies (mAb) have been shown to reduce tumor size
and increase survival in patients with breast cancer, but they are ineffective against brain
metastases due to poor brain penetration. In previous studies, we identified a peptide, …
and increase survival in patients with breast cancer, but they are ineffective against brain
metastases due to poor brain penetration. In previous studies, we identified a peptide, …
Use of peripheral blood cells for cardiac regeneration
E Yeh – US Patent App. 11/091,149, 2005
The present invention concerns methods of improving cardiac function in cardiac tissues of a
recipient host by delivery of peripheral blood derived stem cells. The present invention also
describes methods of stimulating cardiac tissue regeneration in a recipient host. Methods …
recipient host by delivery of peripheral blood derived stem cells. The present invention also
describes methods of stimulating cardiac tissue regeneration in a recipient host. Methods …
Exercise training restores cardiac protein quality control in heart failure
Abstract Exercise training is a well-known coadjuvant in heart failure treatment; however, the
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria …
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria …
In situ immunodetection of antigens
FN Zeytinoglu, FB Thiebaut – US Patent 5,874,226, 1999
An antibody targeted to an antigen is brought into contact with a body component in situ. The
resulting antibody/antigen complex is labeled and may be amplified. The label is then detected
either in situ or ex situ. … 2. The method of claim 1 wherein the body component …
resulting antibody/antigen complex is labeled and may be amplified. The label is then detected
either in situ or ex situ. … 2. The method of claim 1 wherein the body component …
Endorepellin, the Angiostatic Module of Perlecan, Interacts with Both the α2β1 Integrin and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) A DUAL …
Abstract Endorepellin, the C-terminal module of perlecan, negatively regulates
angiogenesis counter to its proangiogenic parental molecule. Endorepellin (the C-terminal
domain V of perlecan) binds the α2β1 integrin on endothelial cells and triggers a signaling …
angiogenesis counter to its proangiogenic parental molecule. Endorepellin (the C-terminal
domain V of perlecan) binds the α2β1 integrin on endothelial cells and triggers a signaling …
The antiprogestin Lonaprisan inhibits breast cancer cell proliferation by inducing p21 expression
L Busia, H Faus, J Hoffmann, B Haendler – Molecular and cellular endocrinology, 2011
The ovarian steroid hormone progesterone is essential for normal mammary gland
physiology but may also play a role in breast cancer. Highly potent and selective
antiprogestins may therefore represent a new treatment option for this disease. Here we …
physiology but may also play a role in breast cancer. Highly potent and selective
antiprogestins may therefore represent a new treatment option for this disease. Here we …
Increased sensitivity to TRAIL-induced apoptosis occurs during the adenoma to carcinoma transition of colorectal carcinogenesis
A Hague, DJ Hicks, F Hasan, H Smartt, GM Cohen… – British journal of cancer, 2005
Abstract The death ligand TRAIL (Apo2L) has potential for cancer therapy, since tumour
cells are thought to be more sensitive than normal cells. We investigated whether sensitivity
to TRAIL increases during the adenoma to carcinoma transition of colorectal …
cells are thought to be more sensitive than normal cells. We investigated whether sensitivity
to TRAIL increases during the adenoma to carcinoma transition of colorectal …
Freeze-thaw stress of Alhydrogel® alone is sufficient to reduce the immunogenicity of a recombinant hepatitis B vaccine containing native antigen
T Clapp, MW Munks, R Trivedi, UB Kompella… – Vaccine, 2014
Abstract Preventing losses in vaccine potency due to accidental freezing has recently
become a topic of interest for improving vaccines. All vaccines with aluminum-containing
adjuvants are susceptible to such potency losses. Recent studies have described …
become a topic of interest for improving vaccines. All vaccines with aluminum-containing
adjuvants are susceptible to such potency losses. Recent studies have described …
Regulator of calmodulin signaling knockout mice display anxiety‐like behavior and motivational deficits
MM Davis, P Olausson, P Greengard, JR Taylor… – European Journal of …, 2012
Abstract Regulator of calmodulin (CaM) signaling (RCS), when phosphorylated by protein
kinase A (PKA) on Ser55, binds to CaM and inhibits CaM-dependent signaling. RCS
expression is high in the dorsal striatum, nucleus accumbens and amygdala, suggesting …
kinase A (PKA) on Ser55, binds to CaM and inhibits CaM-dependent signaling. RCS
expression is high in the dorsal striatum, nucleus accumbens and amygdala, suggesting …
Evaluation of influenza-specific humoral response by microbead array analysis
Y Keynan, T Bodnarchuk, S Wayne, Y Li, KR Fowke – Canadian Journal of …, 2011
RATIONALE: Quantitation and determination of antigen specificity of systemic and mucosal
immune responses to influenza vaccination is beneficial for future vaccine development.
Previous methods to acquire this information were costly, time consuming and sample …
immune responses to influenza vaccination is beneficial for future vaccine development.
Previous methods to acquire this information were costly, time consuming and sample …
Orthobunyavirus entry into neurons and other mammalian cells occurs via clathrin-mediated endocytosis and requires trafficking into early endosomes
BS Hollidge, NB Nedelsky, MV Salzano, JW Fraser… – Journal of virology, 2012
ABSTRACT La Crosse virus (LACV) is a leading cause of pediatric encephalitis and aseptic
meningitis in the midwestern and southern United States, where it is considered an
emerging human pathogen. No specific therapies or vaccines are available for LACV or …
meningitis in the midwestern and southern United States, where it is considered an
emerging human pathogen. No specific therapies or vaccines are available for LACV or …
Bispecific antibodies
R Lee, J Larrick, L Lum – US Patent App. 11/170,716, 2005
The present invention provides compositions and methods
for targeting stem cells to injured cardiac tissue.
for targeting stem cells to injured cardiac tissue.
IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer
P Kachroo, MH Lee, L Zhang, F Baratelli, G Lee… – Journal of Experimental & …, 2013
Background Interleukin-27 signaling is mediated by the JAK-STAT pathway via activation of
STAT1 and STAT3, which have tumor suppressive and oncogenic activities, respectively.
Epithelial–mesenchymal transition (EMT) and angiogenesis are key processes in …
STAT1 and STAT3, which have tumor suppressive and oncogenic activities, respectively.
Epithelial–mesenchymal transition (EMT) and angiogenesis are key processes in …
TgGRA23, a novel Toxoplasma gondii dense granule protein associated with the parasitophorous vacuole membrane and intravacuolar network
T Masatani, T Matsuo, T Tanaka, MA Terkawi, EG Lee… – Parasitology international, 2013
Toxoplasma gondii is an intracellular protozoan parasite, which relies on a specialized
compartment, the parasitophorous vacuole (PV), to survive within host cells. Dense granules
within the parasite release a large variety of proteins to maintain the integrity of the …
compartment, the parasitophorous vacuole (PV), to survive within host cells. Dense granules
within the parasite release a large variety of proteins to maintain the integrity of the …
SkM1 and Cx32 improve conduction in canine myocardial infarcts yet only SkM1 is antiarrhythmic
GJJ Boink, DH Lau, IN Shlapakova, EA Sosunov… – Cardiovascular research, 2012
Aims Reentry accounts for most life-threatening arrhythmias, complicating myocardial
infarction, and therapies that consistently prevent reentry from occurring are lacking. In this
study, we compare antiarrhythmic effects of gene transfer of green fluorescent protein ( …
infarction, and therapies that consistently prevent reentry from occurring are lacking. In this
study, we compare antiarrhythmic effects of gene transfer of green fluorescent protein ( …
Increased Cell-Cell Coupling Increases Infarct Size and Does not Decrease Incidence of Ventricular Tachycardia in Mice.
KA Prestia, EA Sosunov, EP Anyukhovsky… – Front Physiol, 2011
Increasing connexin43 (Cx43) gap junctional conductance as a means to improve cardiac
conduction has been proposed as a novel antiarrhythmic modality. Yet, transmission of
molecules via gap junctions may be associated with increased infarct size. To determine …
conduction has been proposed as a novel antiarrhythmic modality. Yet, transmission of
molecules via gap junctions may be associated with increased infarct size. To determine …
Transforming growth factor β1 increase of hydroxysteroid dehydrogenase proteins is partly suppressed by red clover isoflavones in human primary prostate cancer- …
X Liu, YS Piao, JT Arnold – Carcinogenesis, 2011
Abstract Transforming growth factor β1 (TGF-β1) increases dehydro-epiandrosterone
(DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue
model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover ( …
(DHEA) metabolism to androgens and prostate-specific antigen (PSA) in a prostate tissue
model where stromal (6S) cells and epithelial (LAPC-4) cells are cocultured. Red clover ( …
A “two-hit” hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport
GS Pesiridis, K Tripathy, S Tanik, JQ Trojanowski… – Journal of Biological …, 2011
Abstract Carboxyl-terminal fragments (CTFs) of TDP-43 aggregate to form the diagnostic
signature inclusions of frontotemporal lobar degeneration and amyotrophic lateral sclerosis,
but the biological significance of these CTFs and how they are generated remain …
signature inclusions of frontotemporal lobar degeneration and amyotrophic lateral sclerosis,
but the biological significance of these CTFs and how they are generated remain …
EFhd2 is a novel amyloid protein associated with pathological tau in Alzheimer’s disease
Y Ferrer‐Acosta, EN Rodríguez‐Cruz, F Orange… – Journal of neurochemistry, 2013
Abstract EFhd2 is a conserved calcium-binding protein, abundant within the central nervous
system. Previous studies identified EFhd2 associated with pathological forms of tau proteins
in the tauopathy mouse model JNPL3, which expresses the human tau P301L mutant. …
system. Previous studies identified EFhd2 associated with pathological forms of tau proteins
in the tauopathy mouse model JNPL3, which expresses the human tau P301L mutant. …
Resveratrol targeting of carcinogen-induced brain endothelial cell inflammation biomarkers MMP-9 and COX-2 is Sirt1-independent
B Annabi, S Lord-Dufour, A Vézina, R Béliveau – Drug Target Insights, 2012
Abstract The occurrence of a functional relationship between the release of
metalloproteinases (MMPs) and the expression of cyclooxygenase (COX)-2, two inducible
pro-inflammatory biomarkers with important pro-angiogenic effects, has recently been …
metalloproteinases (MMPs) and the expression of cyclooxygenase (COX)-2, two inducible
pro-inflammatory biomarkers with important pro-angiogenic effects, has recently been …
Increased propensity for cell death in diabetic human
R Chitwood, AP Kypson – Am J Physiol Heart Circ Physiol, 2011
METHODS Clinical data and patient demographics. The University and Medical Center
Institutional Review Board approved all aspects of patient recruitment and informed consent
for this study. Cohorts evaluated were diabetic and nondiabetic patients at the East …
Institutional Review Board approved all aspects of patient recruitment and informed consent
for this study. Cohorts evaluated were diabetic and nondiabetic patients at the East …
Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells
S Winsel, A Sommer, J Eschenbrenner, K Mittelstaedt… – PloS one, 2011
Abstract Sagopilone, an optimized fully synthetic epothilone, is a microtubule-stabilizing
compound that has shown high in vitro and in vivo activity against a broad range of human
tumor models. We analyzed the differential mechanism of action of sagopilone in non- …
compound that has shown high in vitro and in vivo activity against a broad range of human
tumor models. We analyzed the differential mechanism of action of sagopilone in non- …
Aldehydic load and aldehyde dehydrogenase 2 profile during the progression of post-myocardial infarction cardiomyopathy: Benefits of Alda-1
KMS Gomes, LRG Bechara, VM Lima, MAC Ribeiro… – International journal of …, 2015
Methods Here we characterized cardiac ALDH2 activity and expression, lipid peroxidation, 4-
hydroxy-2-nonenal (4-HNE) adduct formation, glutathione pool and mitochondrial energy
metabolism and H 2 O 2 release during the 4 weeks after permanent left anterior …
hydroxy-2-nonenal (4-HNE) adduct formation, glutathione pool and mitochondrial energy
metabolism and H 2 O 2 release during the 4 weeks after permanent left anterior …
Prevention of murine lupus nephritis by targeting multiple signaling axes and oxidative stress using a synthetic triterpenoid
Objective Current treatment options for lupus are far from optimal. Previously, we reported
that phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, MEK-1/ERK-1, 2,
p38, STAT-3, STAT-5, NF-κB, multiple Bcl-2 family members, and various cell cycle …
that phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin, MEK-1/ERK-1, 2,
p38, STAT-3, STAT-5, NF-κB, multiple Bcl-2 family members, and various cell cycle …
Kaposi’s Sarcoma–Associated Herpesvirus-Encoded Interleukin-6 and G-Protein–Coupled Receptor Regulate Angiopoietin-2 Expression in Lymphatic Endothelial …
RJ Vart, LL Nikitenko, D Lagos, MWB Trotter… – Cancer research, 2007
Abstract Kaposi’s sarcoma (KS) is caused by Kaposi’s sarcoma–associated herpesvirus
(KSHV) and consists of proliferating spindle cells, which are related to lymphatic endothelial
cells (LEC). Angiopoietin-2 (Ang2) is a secreted proangiogenic and lymphangiogenic …
(KSHV) and consists of proliferating spindle cells, which are related to lymphatic endothelial
cells (LEC). Angiopoietin-2 (Ang2) is a secreted proangiogenic and lymphangiogenic …
Ribosomal protein S6 kinase 1 signaling in prefrontal cortex controls depressive behavior
JM Dwyer, JG Maldonado-Avilés, AE Lepack… – Proceedings of the …, 2015
Abstract Current treatments for major depressive disorder (MDD) have a time lag and are
ineffective for a large number of patients. Development of novel pharmacological therapies
requires a comprehensive understanding of the molecular events that contribute to MDD …
ineffective for a large number of patients. Development of novel pharmacological therapies
requires a comprehensive understanding of the molecular events that contribute to MDD …
Combination Treatment with Apricoxib and IL-27 Enhances Inhibition of Epithelial-Mesenchymal Transition in Human Lung Cancer Cells through a STAT1 Dominant …
MH Lee, P Kachroo, PC Pagano, J Yanagawa… – Journal of cancer science & …, 2014
Background The cyclooxygenase 2 (COX-2) pathway has been implicated in the molecular
pathogenesis of many malignancies, including lung cancer. Apricoxib, a selective COX-2
inhibitor, has been described to inhibit epithelial-mesenchymal transition (EMT) in human …
pathogenesis of many malignancies, including lung cancer. Apricoxib, a selective COX-2
inhibitor, has been described to inhibit epithelial-mesenchymal transition (EMT) in human …
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathway
R Naughton, C Quiney, SD Turner, TG Cotter – Leukemia, 2009
Abstract Bcr-Abl causes chronic myelogenous leukemia, a myeloproliferative disorder
characterized by clonal expansion of hematopoietic progenitor cells. In this study, inducible
expression of Bcr-Abl in TonB. 210 cells is associated with increased production of …
characterized by clonal expansion of hematopoietic progenitor cells. In this study, inducible
expression of Bcr-Abl in TonB. 210 cells is associated with increased production of …
Treatment of peritoneal carcinomatosis with intraperitoneal administration of Ad-hARF
BR Rajeshkumar, S Paliwal, L Lambert, SR Grossman… – Journal of Surgical …, 2015
Background Peritoneal dissemination of cancer is a terminal condition with limited
therapeutic options. Because the peritoneal cavity is a single enclosed space, regional
treatment approaches for isolated peritoneal cancrinomatosis are appealing. There is a …
therapeutic options. Because the peritoneal cavity is a single enclosed space, regional
treatment approaches for isolated peritoneal cancrinomatosis are appealing. There is a …
Expression of skeletal muscle sodium channel (Nav1. 4) or connexin32 prevents reperfusion arrhythmias in murine heart
EP Anyukhovsky, EA Sosunov, YN Kryukova, K Prestia… – Cardiovascular research, 2011
Aims Acute myocardial ischaemia induces a decrease in resting membrane potential [which
leads to reduction of action potential (AP) V max] and intracellular acidification (which closes
gap junctions). Both contribute to conduction slowing. We hypothesized that ventricular …
leads to reduction of action potential (AP) V max] and intracellular acidification (which closes
gap junctions). Both contribute to conduction slowing. We hypothesized that ventricular …
Tetracycline derivative minocycline inhibits autophagy and inflammation in concanavalin-a-activated human hepatoma cells
M Desjarlais, J Pratt, A Lounis, C Mounier, K Haidara… – Gene regulation and …, 2014
Abstract Inhibition of soluble matrix metalloproteinase (MMP) activity is among the non-
antibiotic cellular effects exerted by the anti-inflammatory tetracycline derivative minocycline.
The impact of minocycline on the signal transduction functions of membrane-bound MMPs …
antibiotic cellular effects exerted by the anti-inflammatory tetracycline derivative minocycline.
The impact of minocycline on the signal transduction functions of membrane-bound MMPs …
Coordinated involvement of cathepsins S, D and cystatin C in the commitment of hematopoietic stem cells to dendritic cells
S Martino, R Tiribuzi, E Ciraci, G Makrypidi… – The international journal of …, 2011
The identity of biochemical players which underpin the commitment of CD34+ hematopoietic
stem cells to immunogenic or tolerogenic dendritic cells is largely unknown. To explore this
issue, we employed a previously established cell-based system amenable to shift …
stem cells to immunogenic or tolerogenic dendritic cells is largely unknown. To explore this
issue, we employed a previously established cell-based system amenable to shift …
Elevated neutrophil gelatinase-associated lipocalin contributes to erlotinib resistance in non-small cell lung cancer
K Krysan, X Cui, BK Gardner, KL Reckamp, X Wang… – Am J Transl Res, 2013
Abstract: Purpose: The EGFR tyrosine kinase inhibitors (TKIs) demonstrate efficacy in
NSCLC patients whose tumors harbor activating EGFR mutations. However, patients who
initially respond to EGFR TKI treatment invariably develop resistance to the drugs. Known …
NSCLC patients whose tumors harbor activating EGFR mutations. However, patients who
initially respond to EGFR TKI treatment invariably develop resistance to the drugs. Known …
Optimizing the parameters of vagus nerve stimulation by uniform design in rats with acute myocardial infarction
SS Kong, JJ Liu, TC Hwang, XJ Yu, M Zhao, M Zhao… – PloS one, 2012
Abstract Vagus nerve stimulation (VNS) has been shown to improve left ventricular function
and survival in rats with acute myocardial infarction (AMI), and this maneuver has also been
adopted clinically for the treatment of patients with chronic heart failure (CHF). Recent in …
and survival in rats with acute myocardial infarction (AMI), and this maneuver has also been
adopted clinically for the treatment of patients with chronic heart failure (CHF). Recent in …
Exercise training restores cardiac protein quality control in heart failure
JC Campos, BB Queliconi, PMM Dourado, TF Cunha… – PLoS One, 2012
Abstract Exercise training is a well-known coadjuvant in heart failure treatment; however, the
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria …
molecular mechanisms underlying its beneficial effects remain elusive. Despite the primary
cause, heart failure is often preceded by two distinct phenomena: mitochondria …
Aerobic exercise training upregulates skeletal muscle calpain and ubiquitin-proteasome systems in healthy mice
TF Cunha, JBN Moreira, NA Paixão, JC Campos… – Journal of applied …, 2012
Abstract Aerobic exercise training (AET) is an important mechanical stimulus that modulates
skeletal muscle protein turnover, leading to structural rearrangement. Since the ubiquitin-
proteasome system (UPS) and calpain system are major proteolytic pathways involved in …
skeletal muscle protein turnover, leading to structural rearrangement. Since the ubiquitin-
proteasome system (UPS) and calpain system are major proteolytic pathways involved in …
Regional rescue of spinocerebellar ataxia type 1 phenotypes by 14-3-3ε haploinsufficiency in mice underscores complex pathogenicity in neurodegeneration
P Jafar-Nejad, CS Ward, R Richman, HT Orr… – Proceedings of the …, 2011
Abstract Spinocerebellar ataxia type 1 (SCA1) is a neurodegenerative disease caused by
the expansion of a CAG repeat encoding a polyglutamine tract in Ataxin-1 (ATXN1). Both WT
and mutant ATXN1 interact with 14-3-3 proteins, and 14-3-3 overexpression stabilizes …
the expansion of a CAG repeat encoding a polyglutamine tract in Ataxin-1 (ATXN1). Both WT
and mutant ATXN1 interact with 14-3-3 proteins, and 14-3-3 overexpression stabilizes …
Small ubiquitin-like modifier (SUMO) isoforms and conjugation-independent function in DNA double-strand break repair pathways
Y Hu, JD Parvin – Journal of Biological Chemistry, 2014
↵1 To whom correspondence should be addressed: Dept. of Biomedical Informatics, Ohio State
University, 460 W. 12th Ave., Columbus, OH 43210. Tel.: 614-292-0523; E-mail:
Jeffrey.Parvin{at}osumc.edu. … Background: The SUMO system is involved in …
University, 460 W. 12th Ave., Columbus, OH 43210. Tel.: 614-292-0523; E-mail:
Jeffrey.Parvin{at}osumc.edu. … Background: The SUMO system is involved in …
Calcium sensitization of cardiac myofilament proteins contributes to exercise training-enhanced myocardial function in a porcine model of chronic occlusion
M Muthuchamy, CL Heaps – American Journal of Physiology-Heart and …, 2011
Abstract Exercise training has been shown to improve cardiac dysfunction both in patients
and animal models of coronary artery disease; however, the underlying cellular and
molecular mechanisms have not been completely understood. We hypothesized that …
and animal models of coronary artery disease; however, the underlying cellular and
molecular mechanisms have not been completely understood. We hypothesized that …
Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression
L Yin, P Rao, P Elson, J Wang, M Ittmann… – PLoS One, 2011
Abstract Prostate specific membrane antigen (PSMA) is overexpressed in prostatic
adenocarcinoma (CaP), and its expression is negatively regulated by androgen stimulation.
However, it is still unclear which factors are involved in this downregulation. TMPRSS2- …
adenocarcinoma (CaP), and its expression is negatively regulated by androgen stimulation.
However, it is still unclear which factors are involved in this downregulation. TMPRSS2- …
Tissue kallikrein-modified human endothelial progenitor cell implantation improves cardiac function via enhanced activation of akt and increased angiogenesis
Y Yao, Z Sheng, Y Li, C Fu, G Ma, N Liu, J Chao… – Laboratory Investigation, 2013
Abstract Endothelial progenitor cells (EPCs) have been shown to enhance angiogenesis not
only by incorporating into the vasculature but also by secreting cytokines, thereby serving as
an ideal vehicle for gene transfer. As tissue kallikrein (TK) has pleiotropic effects in …
only by incorporating into the vasculature but also by secreting cytokines, thereby serving as
an ideal vehicle for gene transfer. As tissue kallikrein (TK) has pleiotropic effects in …
Antidepressant-like properties of oral riluzole and utility of incentive disengagement models of depression in mice
SL Gourley, JW Espitia, G Sanacora, JR Taylor – Psychopharmacology, 2012
Abstract Rationale The neuroprotective agent riluzole has antidepressant-like properties in
humans, but its mechanisms of action are unclear. Despite the increasing utility of transgenic
and knockout mice in addressing such issues, previous studies aimed at characterizing …
humans, but its mechanisms of action are unclear. Despite the increasing utility of transgenic
and knockout mice in addressing such issues, previous studies aimed at characterizing …
Single low-dose un-adjuvanted HBsAg nanoparticle vaccine elicits robust, durable immunity
AA Lugade, DJ Bharali, V Pradhan, G Elkin… – … , Biology and Medicine, 2013
Abstract Chitosan nanoparticles were evaluated as a vaccine delivery system for hepatitis B
surface antigen (HBsAg) in the absence of adjuvant. Nano-encapsulated HBsAg (HBsAg
chitosan-NP) was endocytosed more rapidly and efficiently by dendritic cells compared to …
surface antigen (HBsAg) in the absence of adjuvant. Nano-encapsulated HBsAg (HBsAg
chitosan-NP) was endocytosed more rapidly and efficiently by dendritic cells compared to …
Tau loss attenuates neuronal network hyperexcitability in mouse and Drosophila genetic models of epilepsy
JK Holth, VC Bomben, JG Reed, T Inoue, L Younkin… – The Journal of …, 2013
Abstract Neuronal network hyperexcitability underlies the pathogenesis of seizures and is a
component of some degenerative neurological disorders such as Alzheimer’s disease (AD).
Recently, the microtubule-binding protein tau has been implicated in the regulation of …
component of some degenerative neurological disorders such as Alzheimer’s disease (AD).
Recently, the microtubule-binding protein tau has been implicated in the regulation of …
siRNA nanocarriers based on methacrylic acid copolymers
AE Felber, B Castagner, M Elsabahy, GF Deleavey… – Journal of controlled …, 2011
Poly (ethylene glycol)-b-poly (propyl methacrylate-co-methacrylic acid)(PEG-bP (PrMA-co-
MAA) can be complexed with poly (amido amine)(PAMAM) dendrimers and nucleic acids to
form pH-responsive nanosized core-shell type polyion complex micelles (PICMs). These …
MAA) can be complexed with poly (amido amine)(PAMAM) dendrimers and nucleic acids to
form pH-responsive nanosized core-shell type polyion complex micelles (PICMs). These …
The orbitofrontal cortex regulates outcome‐based decision‐making via the lateral striatum
SL Gourley, A Olevska, KS Zimmermann, KJ Ressler… – European Journal of …, 2013
Abstract The orbitofrontal cortex (oPFC) sends substantial projections to the ventrolateral
striatum and aspects of the nucleus accumbens that are, functionally, poorly understood.
This is despite probable cortico-striatal involvement in multiple diseases such as addiction …
striatum and aspects of the nucleus accumbens that are, functionally, poorly understood.
This is despite probable cortico-striatal involvement in multiple diseases such as addiction …
Integrative effect of carvedilol and aerobic exercise training therapies on improving cardiac contractility and remodeling in heart failure mice
AS Vanzelli, A Medeiros, N Rolim, JB Bartholomeu… – PloS one, 2013
Abstract The use of β-blockers is mandatory for counteracting heart failure (HF)-induced
chronic sympathetic hyperactivity, cardiac dysfunction and remodeling. Importantly, aerobic
exercise training, an efficient nonpharmacological therapy to HF, also counteracts …
chronic sympathetic hyperactivity, cardiac dysfunction and remodeling. Importantly, aerobic
exercise training, an efficient nonpharmacological therapy to HF, also counteracts …
Role of the transcription factor T (brachyury) in the pathogenesis of sporadic chordoma: a genetic and functional‐based study
N Presneau, A Shalaby, H Ye, N Pillay, D Halai… – The Journal of pathology, 2011
Abstract A variety of analyses, including fluorescence in situ hybridization (FISH),
quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of
chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T …
quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series of
chordomas from 181 patients. Twelve of 181 (7%) tumours displayed amplification of the T …
Expression profile of NSDHL in human peripheral tissues
M Morimoto, C Du Souich, J Trinh, KW McLarren… – Journal of molecular …, 2012
Abstract NAD (P) steroid dehydrogenase-like (NSDHL) is an X-linked gene that encodes a
3β-hydroxysteroid dehydrogenase in the cholesterol biosynthetic pathway. Loss-of-function
mutations in NSDHL cause Congenital Hemidysplasia with Ichthyosiform erythroderma …
3β-hydroxysteroid dehydrogenase in the cholesterol biosynthetic pathway. Loss-of-function
mutations in NSDHL cause Congenital Hemidysplasia with Ichthyosiform erythroderma …
Targeting activated Akt with GDC-0068, a novel selective Akt inhibitor that is efficacious in multiple tumor models
J Lin, D Sampath, MA Nannini, BB Lee, M Degtyarev… – Clinical Cancer Research, 2013
Results: GDC-0068 blocked Akt signaling both in cultured human cancer cell lines and in tumor
xenograft models as evidenced by dose-dependent decrease in phosphorylation of downstream
targets. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle …
xenograft models as evidenced by dose-dependent decrease in phosphorylation of downstream
targets. Inhibition of Akt activity by GDC-0068 resulted in blockade of cell-cycle …
MicroRNA profiling of peripheral nerve sheath tumours identifies miR-29c as a tumour suppressor gene involved in tumour progression
N Presneau, M Eskandarpour, T Shemais… – British journal of cancer, 2013
Background: Neurofibromatosis type 1 is one of the most common familial diseases, the
hallmark of which is the development of multiple neurofibromas. These are benign nerve
sheath tumours, which can transform into malignant peripheral nerve sheath tumours ( …
hallmark of which is the development of multiple neurofibromas. These are benign nerve
sheath tumours, which can transform into malignant peripheral nerve sheath tumours ( …
Baroreflex deficiency induces additional impairment of vagal tone, diastolic function and calcium handling proteins after myocardial infarction
C Mostarda, B Rodrigues, A Medeiros, ED Moreira… – American journal of …, 2014
Abstract Baroreflex dysfunction has been considered an important mortality predictor after
myocardial infarction (MI). However, the impact of baroreflex deficiency prior to MI on tonic
autonomic control and cardiac function, and on the profile of proteins associated with …
myocardial infarction (MI). However, the impact of baroreflex deficiency prior to MI on tonic
autonomic control and cardiac function, and on the profile of proteins associated with …
Wnt-mediated activation of NeuroD1 and retro-elements during adult neurogenesis
Abstract In adult hippocampus, new neurons are continuously generated from neural stem
cells (NSCs), but the molecular mechanisms regulating adult neurogenesis remain elusive.
We found that Wnt signaling, together with the removal of Sox2, triggered the expression …
cells (NSCs), but the molecular mechanisms regulating adult neurogenesis remain elusive.
We found that Wnt signaling, together with the removal of Sox2, triggered the expression …
Scopolamine rapidly increases mTORC1 signaling, synaptogenesis, and antidepressant behavioral responses
B Voleti, A Navarria, RJ Liu, M Banasr, N Li… – Biological psychiatry, 2013
Background Clinical studies report that scopolamine, an acetylcholine muscarinic receptor
antagonist, produces rapid antidepressant effects in depressed patients, but the
mechanisms underlying the therapeutic response have not been determined. The present …
antagonist, produces rapid antidepressant effects in depressed patients, but the
mechanisms underlying the therapeutic response have not been determined. The present …
Altered TUBB3 expression contributes to the epothilone response of mitotic cells
E Narvi, K Jaakkola, S Winsel, C Oetken-Lindholm… – British journal of cancer, 2013
Background: Epothilones are a novel group of microtubule (mt) targeting cancer drugs that
bind to the β-subunit of the α β-tubulin dimer. Epothilones inhibit cell proliferation and induce
cell death by interfering with the normal mt function. In this study, we examined the …
bind to the β-subunit of the α β-tubulin dimer. Epothilones inhibit cell proliferation and induce
cell death by interfering with the normal mt function. In this study, we examined the …
Tumour necrosis factor‐α and its receptors in the beneficial effects of vagal stimulation after myocardial infarction in rats
SS Kong, JJ Liu, TC Hwang, XJ Yu, Y Lu, WJ Zang – Clinical and Experimental …, 2011
SUMMARY 1. Acute myocardial infarction (AMI) often activates the sympathetic system and
inhibits the vagal system. Long-term vagal nerve stimulation (VNS) exerts several beneficial
effects on the ischaemic heart, including an anti-inflammatory effect. The aim of the …
inhibits the vagal system. Long-term vagal nerve stimulation (VNS) exerts several beneficial
effects on the ischaemic heart, including an anti-inflammatory effect. The aim of the …
The EPI bioassay identifies natural compounds with estrogenic activity that are potent inhibitors of androgenic pathways in human prostate stromal and epithelial cells
G Vollmer, J Helle, H Amri, X Liu, JT Arnold – The Journal of steroid biochemistry …, 2012
The reactive stromal phenotype is an important factor for prostate cancer progression and
may be a new target for treatment and prevention. A new high efficiency preclinical protocol,
the EPI bioassay, reflects the interaction of endocrine, paracrine and immune,(EPI) factors …
may be a new target for treatment and prevention. A new high efficiency preclinical protocol,
the EPI bioassay, reflects the interaction of endocrine, paracrine and immune,(EPI) factors …
Evaluation of a high‐sensitivity assay for measurement of canine and feline serum cardiac troponin I
R Langhorn, JL Willesen, I Tarnow… – Veterinary Clinical …, 2013
Background Cardiac troponins are established as the gold standard biomarkers for acute
cardiac injury. As even small elevations of cardiac troponins have prognostic relevance in
people, it is important to investigate the performance of sensitive assays for use in …
cardiac injury. As even small elevations of cardiac troponins have prognostic relevance in
people, it is important to investigate the performance of sensitive assays for use in …
Sigma-1 receptor alters the kinetics of Kv1. 3 voltage gated potassium channels but not the sensitivity to receptor ligands
M Kinoshita, Y Matsuoka, T Suzuki, J Mirrielees, J Yang – Brain research, 2012
Sigma1 receptors (Sigma1R) are intracellular chaperone proteins that bind psychotropic
drugs and also clinically used drugs such as ketamine and haloperidol. Co-expression of
the Sigma1R has been reported to enhance the sensitivity of several voltage-gated ion …
drugs and also clinically used drugs such as ketamine and haloperidol. Co-expression of
the Sigma1R has been reported to enhance the sensitivity of several voltage-gated ion …
Ca2+ sensitization of cardiac myofilament proteins contributes to exercise training-enhanced myocardial function in a porcine model of chronic occlusion
V Sarin, M Muthuchamy, CL Heaps – American Journal of Physiology-Heart and …, 2011
Abstract Exercise training has been shown to improve cardiac dysfunction in both patients
and animal models of coronary artery disease; however, the underlying cellular and
molecular mechanisms have not been completely understood. We hypothesized that …
and animal models of coronary artery disease; however, the underlying cellular and
molecular mechanisms have not been completely understood. We hypothesized that …
Rapid and sensitive detection of troponin ITC complex from human serum using microwave-accelerated metal-enhanced fluorescence
K Aslan – Nano biomedicine and engineering, 2011
Abstract We present the rapid and sensitive detection of Troponin ITC (Tn ITC) complex from
buffer and human serum samples using Microwave-Accelerated and Metal-Enhanced
Fluorescence (MA-MEF) technique, which is based on the combined use of low power …
buffer and human serum samples using Microwave-Accelerated and Metal-Enhanced
Fluorescence (MA-MEF) technique, which is based on the combined use of low power …
Lipoprotein (a) promotes smooth muscle cell proliferation and dedifferentiation in atherosclerotic lesions of human apo (a) transgenic rabbits
T Ichikawa, H Unoki, H Sun, H Shimoyamada… – The American journal of …, 2002
Elevated plasma lipoprotein (a)[Lp (a)] levels constitute an independent risk factor for the
development of atherosclerosis. However, the mechanism underlying Lp (a) atherogenicity
is unclear. Recently, we demonstrated that Lp (a) may potentially be proatherogenic in …
development of atherosclerosis. However, the mechanism underlying Lp (a) atherogenicity
is unclear. Recently, we demonstrated that Lp (a) may potentially be proatherogenic in …
Human monoclonal antibodies to sialyl-Lewisa (CA19. 9) with potent CDC, ADCC, and antitumor activity
R Sawada, SM Sun, X Wu, F Hong, G Ragupathi… – Clinical Cancer Research, 2011
Purpose: The carbohydrate antigen sialyl-Lewis a (sLe a), also known as CA19. 9, is widely
expressed on epithelial tumors of the gastrointestinal tract and breast and on small-cell lung
cancers. Since overexpression of sLe a appears to be a key event in invasion and …
expressed on epithelial tumors of the gastrointestinal tract and breast and on small-cell lung
cancers. Since overexpression of sLe a appears to be a key event in invasion and …
Systemic gene delivery in large species for targeting spinal cord, brain, and peripheral tissues for pediatric disorders
Abstract Adeno-associated virus type 9 (AAV9) is a powerful tool for delivering genes
throughout the central nervous system (CNS) following intravenous injection. Preclinical
results in pediatric models of spinal muscular atrophy (SMA) and lysosomal storage …
throughout the central nervous system (CNS) following intravenous injection. Preclinical
results in pediatric models of spinal muscular atrophy (SMA) and lysosomal storage …
Molecular imaging of mesenchymal stem cell mechanistic insight into cardiac repair after experimental myocardial infarction
J Wang, A Najjar, S Zhang, B Rabinovich… – Circulation: Cardiovascular …, 2012
Background—Mesenchymal stem cells (MSCs) can differentiate into endothelial cells in
vivo. However, it is unknown if the differentiated MSCs persist in vivo and if this potential
persistence contributes to functional improvement after experimental myocardial infarction.
vivo. However, it is unknown if the differentiated MSCs persist in vivo and if this potential
persistence contributes to functional improvement after experimental myocardial infarction.
Rapid and sensitive detection of troponin I in human whole blood samples by using silver nanoparticle films and microwave heating
K Aslan, TAJ Grell – Clinical chemistry, 2011
BACKGROUND: Cardiovascular diseases are among the leading causes of mortality in
developed countries. It is widely recognized that troponin I (TnI) can be used for the
assessment of a myocardial infarction. METHODS: We investigated the use of the …
developed countries. It is widely recognized that troponin I (TnI) can be used for the
assessment of a myocardial infarction. METHODS: We investigated the use of the …
Mesenchymal stromal cell ciliogenesis is abrogated in response to tumor necrosis factor-α and requires NF-κB signaling
A Vézina, E Vaillancourt-Jean, S Albarao, B Annabi – Cancer letters, 2014
Abstract The primary cilium is a cell surface-anchored sensory organelle which expression
is lost in hypoxic cancer cells and during mesenchymal stromal cells (MSC) adaptation to
low oxygen levels. Since pro-inflammatory cues are among the early events which …
is lost in hypoxic cancer cells and during mesenchymal stromal cells (MSC) adaptation to
low oxygen levels. Since pro-inflammatory cues are among the early events which …
Time-dependent degradation pattern of cardiac troponin T following myocardial infarction
EPM Cardinaels, AMA Mingels, T van Rooij… – Clinical chemistry, 2013
BACKGROUND: Cardiac troponin T (cTnT) is widely used for the diagnosis of acute
myocardial infarction (AMI). However, it is still unclear whether degraded cTnT forms
circulate in the patient’s blood. We therefore aimed to elucidate which cTnT forms are …
myocardial infarction (AMI). However, it is still unclear whether degraded cTnT forms
circulate in the patient’s blood. We therefore aimed to elucidate which cTnT forms are …
Cytoskeletal determinants of stimulus-response habits
SL Gourley, A Olevska, J Gordon, JR Taylor – The Journal of Neuroscience, 2013
Abstract Both humans and rodents can learn to associate specific actions with their
outcomes, but with repeated performance or exposure to pathological stimuli, such as drugs
of abuse, behaviors assume stimulus-elicited, or “habitual,” qualities. Psychostimulants …
outcomes, but with repeated performance or exposure to pathological stimuli, such as drugs
of abuse, behaviors assume stimulus-elicited, or “habitual,” qualities. Psychostimulants …
Exercise ameliorates the detrimental effect of chloroquine on skeletal muscles in mice via restoring autophagy flux
D Jiang, K Chen, X Lu, H Gao, Z Qin, F Lin – Acta pharmacologica Sinica, 2014
Aim: To study the roles of autophagy in muscle establishment during long-term exercise in
mice. Methods: Female ICR mice were submitted to exercise training with a wheel running
regimen: 6 m/min, 15 min/time, 3 times/d (on 8: 00, 14: 00, and 20: 00), 5 d/week for 2 …
mice. Methods: Female ICR mice were submitted to exercise training with a wheel running
regimen: 6 m/min, 15 min/time, 3 times/d (on 8: 00, 14: 00, and 20: 00), 5 d/week for 2 …
Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice
N Omata, CT Chiu, PR Moya, Y Leng, Z Wang… – International Journal of …, 2011
Abstract Inhibition of glycogen synthase kinase-3 (GSK-3) by pharmacological tools can
produce antidepressant-like effects in rodents. However, the GSK-3 isoform (s) and brain
region (s) involved in regulating these behavioural effects remain elusive. We studied the …
produce antidepressant-like effects in rodents. However, the GSK-3 isoform (s) and brain
region (s) involved in regulating these behavioural effects remain elusive. We studied the …
PKCδ activation mediates angiogenesis via NADPH oxidase activity in PC‐3 prostate cancer cells
J Kim, T Koyanagi, D Mochly‐Rosen – The Prostate, 2011
BACKGROUND PKCδ is generally known as a pro-apoptotic and anti-proliferative enzyme
in human prostate cancer cells. METHODS Here, we investigated the role of PKCδ on the
growth of PC-3 human prostate cancer cells in vivo and in vitro. RESULTS We found that …
in human prostate cancer cells. METHODS Here, we investigated the role of PKCδ on the
growth of PC-3 human prostate cancer cells in vivo and in vitro. RESULTS We found that …
Baroreflex sensitivity impairment is associated with cardiac diastolic dysfunction in rats
Background Studies have shown that the autonomic dysfunction accompanied by impaired
baroreflex sensitivity was associated with higher mortality. However, the influence of
decreased baroreflex sensitivity on cardiac function, especially in diastolic function, is not …
baroreflex sensitivity was associated with higher mortality. However, the influence of
decreased baroreflex sensitivity on cardiac function, especially in diastolic function, is not …
Glutamate N-methyl-D-aspartate receptor antagonists rapidly reverse behavioral and synaptic deficits caused by chronic stress exposure
N Li, RJ Liu, JM Dwyer, M Banasr, B Lee, H Son, XY Li… – Biological psychiatry, 2011
BACKGROUND: Despite widely reported clinical and preclinical studies of rapid
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists,
there has been very little work examining the effects of these drugs in stress models of …
antidepressant actions of glutamate N-methyl-D-aspartate (NMDA) receptor antagonists,
there has been very little work examining the effects of these drugs in stress models of …
Inhibiting the interaction of cMET and IGF-1R with FAK effectively reduces growth of pancreatic cancer cells in vitro and in vivo
DA Ucar, AT Magis, DH He, NJ Lawrence, SM Sebti… – Anti-cancer agents in …, 2013
Abstract Pancreatic cancer is one of the most lethal diseases with no effective treatment.
Previously, we have shown that FAK is overexpressed in pancreatic cancer and plays a key
role in cancer cell survival and proliferation. FAK has been shown to interact with growth …
Previously, we have shown that FAK is overexpressed in pancreatic cancer and plays a key
role in cancer cell survival and proliferation. FAK has been shown to interact with growth …
Sustained inhibition of PKCα reduces intravasation and lung seeding during mammary tumor metastasis in an in vivo mouse model
J Kim, SH Thorne, L Sun, B Huang, D Mochly-Rosen – Oncogene, 2011
Abstract Metastasis is the major reason for breast cancer-related deaths. Although there is a
host of indirect evidence for a role of protein kinase C (PKC) α in primary breast cancer
growth, its role in the molecular pathways leading to metastasis has not been studied …
host of indirect evidence for a role of protein kinase C (PKC) α in primary breast cancer
growth, its role in the molecular pathways leading to metastasis has not been studied …
C-reactive protein and substance use disorders in adolescence and early adulthood: A prospective analysis
EJ Costello, WE Copeland, L Shanahan… – Drug and alcohol …, 2013
Background Dysregulated immune function and elevated inflammation markers are seen in
adults with chronic diseases, including some psychiatric disorders, but evidence on
inflammation in the case of drug abuse is conflicting. Objective To test the concurrent and …
adults with chronic diseases, including some psychiatric disorders, but evidence on
inflammation in the case of drug abuse is conflicting. Objective To test the concurrent and …
Mice lacking the galanin gene show decreased sensitivity to nicotine conditioned place preference
NM Neugebauer, RM Henehan, CA Hales… – … Biochemistry and Behavior, 2011
Previous work has indicated that the neuropeptide galanin decreases sensitivity to the
rewarding effects of morphine and cocaine, but increases alcohol drinking. The aim of the
current study was to examine the role of galanin signaling in nicotine reward by testing the …
rewarding effects of morphine and cocaine, but increases alcohol drinking. The aim of the
current study was to examine the role of galanin signaling in nicotine reward by testing the …
New Imaging Strategies for Prostate Cancer
W Heston – 2010
Abstract: Imaging prostate cancer could be desirable from the perspective of helping tell
where the tumor is, which can also aid the choice of therapeutic approaches and as a
means to quantitate the results of therapy. Best would be the availability of low molecular …
where the tumor is, which can also aid the choice of therapeutic approaches and as a
means to quantitate the results of therapy. Best would be the availability of low molecular …
neural cells comprising a neuroblast and a nestin-positive neural cell; for treating neuronal disorders
FH Gage, J Ray – US Patent 7,732,201, 2010
A method for producing a neuroblast and a cellular composition comprising an enriched
population of neuroblast cells is provided. Also disclosed are methods for identifying
compositions which affect neuroblasts and for treating a subject with a neuronal disorder, …
population of neuroblast cells is provided. Also disclosed are methods for identifying
compositions which affect neuroblasts and for treating a subject with a neuronal disorder, …
mTOR activation is required for the antidepressant effects of mGluR 2/3 blockade
JM Dwyer, AE Lepack, RS Duman – The International Journal of …, 2012
Abstract Recent studies demonstrate that ketamine, a fast-acting antidepressant, rapidly
activates the mammalian target of rapamycin (mTOR) and increases synaptogenesis in the
prefrontal cortex. Because of the side-effect and abuse potential of ketamine we are …
activates the mammalian target of rapamycin (mTOR) and increases synaptogenesis in the
prefrontal cortex. Because of the side-effect and abuse potential of ketamine we are …
Paternal experience suppresses adult neurogenesis without altering hippocampal function in Peromyscus californicus
ER Glasper, Y Kozorovitskiy, A Pavlic, E Gould – Journal of Comparative Neurology, 2011
Abstract Paternal care is rare among mammals, occurring in≈ 6% of species. California
mice (Peromyscus californicus) are unusual; fathers participate extensively in raising their
young and display the same components of parental care as mothers, with the exception …
mice (Peromyscus californicus) are unusual; fathers participate extensively in raising their
young and display the same components of parental care as mothers, with the exception …
Dipeptidyl peptidase-like protein 6 is required for normal electrophysiological properties of cerebellar granule cells
BM Nadin, PJ Pfaffinger – The Journal of Neuroscience, 2010
Abstract In cerebellar granule (CG) cells and many other neurons, A-type potassium currents
play an important role in regulating neuronal excitability, firing patterns, and activity-
dependent plasticity. Protein biochemistry has identified dipeptidyl peptidase-like protein …
play an important role in regulating neuronal excitability, firing patterns, and activity-
dependent plasticity. Protein biochemistry has identified dipeptidyl peptidase-like protein …
Ex vivo stimulation assay for T-cell responses for tuberculosis using LEAPS-peptide heteroconjugates
CB Walton, S Jube, A Schorlemmer, PQ Patek… – Microbiology, 2010
ABSTRACT Infection by virulent strains of Mycobacterium tuberculosis (Mtb) induces a
delayed type hypersensitive (DTH) reaction in all people who may, or may not develop the
tuberculosis disease. Immunization with Mycobacterium bovis, used in the BCG vaccine …
delayed type hypersensitive (DTH) reaction in all people who may, or may not develop the
tuberculosis disease. Immunization with Mycobacterium bovis, used in the BCG vaccine …
L10p and P158DEL DJ‐1 mutations cause protein instability, aggregation, and dimerization impairments
CP Ramsey, BI Giasson – Journal of neuroscience research, 2010
Abstract A variety of mutations in the gene encoding DJ-1 protein cause autosomal
recessive early-onset parkinsonism. Recently, a novel pathogenic homozygous DJ-1
missense mutation resulting in the L10P amino acid substitution was reported. In a …
recessive early-onset parkinsonism. Recently, a novel pathogenic homozygous DJ-1
missense mutation resulting in the L10P amino acid substitution was reported. In a …
Expression of a ricin toxin B subunit: insulin fusion protein in edible plant tissues
JE Carter III, O Odumosu, WHR Langridge – Molecular biotechnology, 2010
Abstract Onset of juvenile Type 1 diabetes (T1D) occurs when autoreactive lymphocytes
progressively destroy the insulin-producing beta-cells in the pancreatic Islets of Langerhans.
The increasing lack of insulin and subsequent onset of hyperglycemia results in increased …
progressively destroy the insulin-producing beta-cells in the pancreatic Islets of Langerhans.
The increasing lack of insulin and subsequent onset of hyperglycemia results in increased …
A chemical screen identifies novel compounds that overcome glial-mediated inhibition of neuronal regeneration
LC Usher, A Johnstone, A Ertürk, Y Hu, D Strikis… – The Journal of …, 2010
Abstract A major barrier to regeneration of CNS axons is the presence of growth-inhibitory
proteins associated with myelin and the glial scar. To identify chemical compounds with the
ability to overcome the inhibition of regeneration, we screened a novel triazine library, …
proteins associated with myelin and the glial scar. To identify chemical compounds with the
ability to overcome the inhibition of regeneration, we screened a novel triazine library, …
Naphthazarin protects against glutamate-induced neuronal death via activation of the Nrf2/ARE pathway
TG Son, EM Kawamoto, QS Yu, NH Greig, MP Mattson… – … and biophysical research …, 2013
Nuclear factor E2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway is an
important cellular stress response pathway involved in neuroprotection. We previously
screened several natural phytochemicals and identified plumbagin as a novel activator of …
important cellular stress response pathway involved in neuroprotection. We previously
screened several natural phytochemicals and identified plumbagin as a novel activator of …
Derangements of post-ischemic cerebral blood flow by protein kinase C delta
HW Lin, RA DeFazio, D Della-Morte, JW Thompson… – Neuroscience, 2010
Cerebral ischemia causes blood flow derangements characterized by hyperemia (increased
cerebral blood flow, CBF) and subsequent hypoperfusion (decreased CBF). We previously
demonstrated that protein kinase C delta (δPKC) plays an important role in hippocampal …
cerebral blood flow, CBF) and subsequent hypoperfusion (decreased CBF). We previously
demonstrated that protein kinase C delta (δPKC) plays an important role in hippocampal …
Traumatic brain injury exacerbates neurodegenerative pathology: improvement with an apolipoprotein E-based therapeutic
DT Laskowitz, P Song, H Wang, B Mace, PM Sullivan… – Journal of neurotrauma, 2010
Abstract Cognitive impairment is common following traumatic brain injury (TBI), and
neuroinflammatory mechanisms may predispose to the development of neurodegenerative
disease. Apolipoprotein E (apoE) polymorphisms modify neuroinflammatory responses, …
neuroinflammatory mechanisms may predispose to the development of neurodegenerative
disease. Apolipoprotein E (apoE) polymorphisms modify neuroinflammatory responses, …
Investigation of release and degradation of cardiac troponin T in patients with acute myocardial infarction
ECHJ Michielsen, JHC Diris, VWVC Kleijnen… – Clinical biochemistry, 2007
OBJECTIVES:: Cardiac troponin T (cTnT) degradation after tissue release is still under
debate. Because degradation of cTnT might have consequences on clearance of the
molecule from the circulation, but also on the assay performance, the aim of this study was …
debate. Because degradation of cTnT might have consequences on clearance of the
molecule from the circulation, but also on the assay performance, the aim of this study was …
Neurogenesis and alterations of neural stem cells in mouse models of cerebral amyloidosis
FV Ermini, S Grathwohl, R Radde, M Yamaguchi… – The American journal of …, 2008
The hippocampus in Alzheimer’s disease is burdened with amyloid plaques and is one of
the few locations where neurogenesis continues throughout adult life. To evaluate the
impact of amyloid-β deposition on neural stem cells, hippocampal neurogenesis was …
the few locations where neurogenesis continues throughout adult life. To evaluate the
impact of amyloid-β deposition on neural stem cells, hippocampal neurogenesis was …
Phosphoproteomic characterization of PYK2 signaling pathways involved in osteogenesis
PC Bonnette, BS Robinson, JC Silva, MP Stokes… – Journal of proteomics, 2010
The PYK2 tyrosine kinase is a negative regulator of bone formation, but aside from the
requirement for PYK2 kinase activity there has been little progress toward understanding of
the molecular mechanism involved in this function. To gain insight into the signaling …
requirement for PYK2 kinase activity there has been little progress toward understanding of
the molecular mechanism involved in this function. To gain insight into the signaling …
Ultrastructural characterization of the optic pathway in a mouse model of neurofibromatosis-1 optic glioma
KY Kim, WK Ju, B Hegedus, DH Gutmann, MH Ellisman – Neuroscience, 2010
The purpose of this study was to investigate the progression of changes in retinal ganglion
cells and optic nerve glia in neurofibromatosis-1 (NF1) genetically-engineered mice with
optic glioma. Optic glioma tumors were generated in Nf1+/− mice lacking Nf1 expression …
cells and optic nerve glia in neurofibromatosis-1 (NF1) genetically-engineered mice with
optic glioma. Optic glioma tumors were generated in Nf1+/− mice lacking Nf1 expression …
Distribution of RGS9‐2 in neurons of the mouse striatum
JJ Mancuso, Y Qian, C Long, GY Wu, TG Wensel – Journal of neurochemistry, 2010
Abstract Regulators of G protein signaling (RGS) proteins negatively modulate G protein-
coupled receptor (GPCR) signaling activity by accelerating G protein hydrolysis of GTP,
hastening pathway shutoff. A wealth of data from cell culture experiments using …
coupled receptor (GPCR) signaling activity by accelerating G protein hydrolysis of GTP,
hastening pathway shutoff. A wealth of data from cell culture experiments using …
Interaction between endometrial epithelial cells and blood leucocytes promotes cytokine release and epithelial barrier function in response to Chlamydia trachomatis …
Abstract Chlamydia trachomatis infection is currently the most common cause of infection-
related sterility in women. However, it remains largely unknown how uterine epithelial cells
interact with recruited leucocytes in response to C. trachomatis infection in the female …
related sterility in women. However, it remains largely unknown how uterine epithelial cells
interact with recruited leucocytes in response to C. trachomatis infection in the female …
Dehydroepiandrosterone administration or Gαq overexpression induces β-catenin/T-cell factor signaling and growth via increasing association of estrogen receptor-β/ …
X Liu, JT Arnold, MR Blackman – Endocrinology, 2010
Although β-catenin/T-cell factor (TCF) (β-CTS) signaling plays multiple critical roles in carcinogenesis
(1, 2), activation of β-CTS by steroid hormones via direct intracellular pathways has not been
identified in prostate cancer (PrCa) cells. Androgens inhibit β-CTS in androgen receptor …
(1, 2), activation of β-CTS by steroid hormones via direct intracellular pathways has not been
identified in prostate cancer (PrCa) cells. Androgens inhibit β-CTS in androgen receptor …
Pharmacological targeting of β-adrenergic receptor functions abrogates NF-κB signaling and MMP-9 secretion in medulloblastoma cells
B Annabi, E Vaillancourt-Jean, AG Weil, R Béliveau – Onco Targets Ther, 2010
Abstract: Targeting of the vascular endothelium compartment explains, in part, the
therapeutic efficacy of the nonselective β-adrenergic antagonist propranolol against
common endothelial tumors such as hemangiomas. In vitro, the antiangiogenic biological …
therapeutic efficacy of the nonselective β-adrenergic antagonist propranolol against
common endothelial tumors such as hemangiomas. In vitro, the antiangiogenic biological …
Expression of FOXL2 in human normal pituitaries and pituitary adenomas
N Egashira, S Takekoshi, M Takei, A Teramoto… – Modern Pathology, 2011
Abstract Many transcription factors have important roles in the function and differentiation of
the human pituitary adenomas. Forkhead box gene transcription factor L2, Foxl2, is
expressed during mouse pituitary development and co-localizes with the expression of α- …
the human pituitary adenomas. Forkhead box gene transcription factor L2, Foxl2, is
expressed during mouse pituitary development and co-localizes with the expression of α- …
Excitability and synaptic communication within the oligodendrocyte lineage
LM De Biase, A Nishiyama, DE Bergles – The Journal of Neuroscience, 2010
Abstract The mammalian CNS contains an abundant, widely distributed population of glial
cells that serve as oligodendrocyte progenitors. It has been reported that these NG2-
immunoreactive cells (NG2+ cells) form synapses and generate action potentials, …
cells that serve as oligodendrocyte progenitors. It has been reported that these NG2-
immunoreactive cells (NG2+ cells) form synapses and generate action potentials, …
Brain-derived neurotrophic factor regulates satellite cell differentiation and skeltal muscle regeneration
C Clow, BJ Jasmin – Molecular biology of the cell, 2010
Abstract In adult skeletal muscle, brain-derived neurotrophic factor (BDNF) is expressed in
myogenic progenitors known as satellite cells. To functionally address the role of BDNF in
muscle satellite cells and regeneration in vivo, we generated a mouse in which BDNF is …
myogenic progenitors known as satellite cells. To functionally address the role of BDNF in
muscle satellite cells and regeneration in vivo, we generated a mouse in which BDNF is …